In TOKYO TSUKIJI MARKET, players run a fishing company. Through the purchase of fishing licenses, they may take fishing actions to fish and put their catch for sale at a price they choose, which other players may purchase on their turn.

The core gameplay centers on an open player-driven economy, with central markets that have limited resources, trading, and unique rules. Each game uses only a fraction of the included game markets, adding endless replayability.

There are two types of currency in the game: yen and resource score. Resource score is equal to yen, with the exception that the player with the most resource at game end receives a yen bonus from the bank, and the player with the least must pay the bank a penalty.